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Zoloft Versus Lexapro: My Experiences with Two Popular Anti-Depressant Medications

Choosing the Right Medication Can Make All the Difference in the World..

By Robbie B, published Sep 05, 2007
Published Content: 98  Total Views: 140,493  Favorited By: 34 CPs
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Many people find that they go through a time where they need an anti-depressant medication at some point during their lives, and deciding which medicine to take can be a very confusing and daunting decision. Zoloft and Lexapro are two popular anti-depressant options, and when patients begin treatment with medication, they are often started on one of these two drugs. I have personal experience with both of these medicines, and in this article I'll compare the pros and cons of both Zoloft and Lexapro.

When I was 16 years old, I experienced my first bout of depression and was prescribed Zoloft by a child psychiatrist. I didn't really know what to expect, and for a few weeks after starting the medicine, I couldn't feel much of an effect at all. After about 4 weeks of taking Zoloft, however, I noticed things were getting better. I moved to a new high school, and soon my depression began to lift. After about 6 months of treatment, I was well enough to stop taking the Zoloft and I figured my problems with depression were behind me.

A few years later, however, I started my freshman year at college and my depression began to return, worse than before. I sought help at the college counseling canter, and after a few sessions with a psychologist, I was referred to the school medical clinic to get a prescription for anti-depressants. Since I had done well on Zoloft when I was younger, the doctor decided I should give it another try, and I immediately resumed taking a daily dose of Zoloft.

Again, I didn't notice much of an effect at first, but within a few weeks my depression began to lift. As I continued my treatment with Zoloft however, I began to experience some strange side effects. The first thing I noticed was that I began to feel emotionally numb. Although I was happy that I wasn't hopelessly depressed, I noticed that nothing really seemed to upset me anymore--even things that it would be perfectly normal & healthy to get upset about. I also wasn't feeling particularly happy about anything, even things that were really exciting going on in my life. I really did just feel numb to the world.

Zoloft Versus Lexapro: My Experiences with Two Popular Anti-Depressant Medications

Two bottles of prescription Zoloft, which is one of the most commonly prescribed medicines to treat depression.

Credit: DrugEducation.net

Copyright: DrugEducation.net

Takeaways
  • Lexapro and Zoloft are two of the most commonly prescribed anti-depressants today.
  • Zoloft has a high incidence of side effects, including side effects that are sexual in nature.
  • Lexapro, on the other hand, has a low occurance of side effects and is usually well-tolerated.
Did You Know?
Lexapro was actually made by isolating the active molecule in it's predecessor drug, Celexa.
Comments
Comments 1 - 11 of 11
 
 
i have taken Zoloft 100 to 200 mg per day. I found that it was not working any more and my psychologist suggested a change. My sister took Lexapro and since we have the same biological makeup and it was working well for her, I thought that might be a good choice even though it seems to be similar to Zoloft. I started the Lexapro at 10 mg and went to 20 mg. As soon as I started the 20 mg dose, it seemed to be causing some side effects namely anxiety and more depression. However, I was told to stick it out so that is what i am doing-we will see

Posted on 08/17/2008 at 7:08:13 PM

 
I've taken both medications. The Zoloft worked well for me, and served its purpose, with no particularly negative sexual side effects. But I had stomach problems when I first started taking it that went away after a couple of weeks. I was on it for about a year, and it did help. For me, the worst part was coming off of it. I had really bad mood swings for about a month or so after I was completely off of it, despite following doctors orders and coming off of it gradually. Lexapro, on the other hand, has been a godsend! I have both depression and anxiety issues, and this is the first drug that has seemed to help manage both well. (Over the years, I've tried several.) I sometimes wonder if I'm building up a tolerance to it, particularly when times are tough. But my wife says she can tell w/in a week if I've stopped taking it. Irritability and anxiety being the 2 most noticeable sympotoms. As another poster says, there's no 1 size fits all, but Lexapro gets my vote

Posted on 07/24/2008 at 8:07:26 PM

 
I have been taking zoloft for a little over a year, I hate the sexual side effects and the feelings I get. I"m going to get my Dr. to prescribe lexapro. thanks for that info.

Posted on 02/15/2008 at 12:02:22 PM

 
Good information to share Robbie - antidepressants are a double-edge sword and response is so unique. It's good to have a well-informed doctor - some tend to have a one-size fits all approach.

Posted on 09/14/2007 at 11:09:00 AM

 
Informative and as a personal testimonial this should be applauded. A buddy of mine took Zoloft but only admitted it to me later on. It's honesty like this from people like Robbie which will chip away at all the outdated stigma silliness of depression and mental ailments. Bravo!!

Posted on 09/08/2007 at 9:09:00 PM

 
Great information!

Posted on 09/08/2007 at 5:09:00 PM

 
Interesting article, thanks. I have friends and family who have experienced the same.

Posted on 09/08/2007 at 3:09:00 PM

 
Good comparison. My son takes Zoloft and describes some of what you wrote. I'll tell him to check into the Lexapro.

Posted on 09/08/2007 at 12:09:00 PM

 
I finally decided that I'd rather live through various degrees of depression than suffer the side effects of anti-depressant medications. I write and use laughter now.

Posted on 09/08/2007 at 9:09:00 AM

 
Interesting article! Thanks for sharing.

Posted on 09/05/2007 at 9:09:00 PM

 
I totally agree with you. Years ago my partner was put on Zoloft, and he experienced the exact same issues with. It actually made him more miserable than he was in the first place! Great article Robbie, as always!

Posted on 09/05/2007 at 8:09:00 AM

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