Grey's Anatomy: Season 4 Premier

The season four premier of Grey's Anatomy is on ABC, September 27^th at 9 pm. "A Change is Gonna Come" is the name of the first episode and the questions for fans is, exactly what changes are we talking about? Fresh off an Emmy win, Katherine Heigle's Izzie Steven's is bound to get some extra attention from the writers this season. Poor Izzie has been through her share of complicated love situations in just three seasons. The third season tragic love affair with patient Denny Duquette (Jeffrey Dean Morgan) left her briefly in Alex's (Justin Chambers) arms after Denny's death and then to her best friend George(T.R. Knight) . In season four, will she be able to put Alex, Denny and George behind her and finally find true love? As a resident now, Izzie may have more contact with both the establish doctors as well as the fresh young interns. After the intensity of the past seasons, she may be ready for a less serious relationship or return to her former beau's?

Will Alex turn up as Izzie's own true love? He may decide to give it one more try. After all, he seemed to realize what he had given up when Izzie fell for patient Denny Duquette. Alex showed some regret at that point and clearly wanted an opportunity to get Izzie back, in the end he was a major supporter of her in the aftermath of Denny's death. Remember Alex carrying a distraught Izzie in her prom dress? While Denny seemed to clearly have been the love of Izzie's life, he died so he is out of the picture. Alex's weird relationship with the amnesic patient last season ended so he is a free man. Alex and Izzie have gone back and forth from the beginning and thought hey are hot together, they're kind of boring. A relationship with Alex could kill Izzie's character and turn her back into the Barbie doll character she started out as in season one.