Permanent Damage Detected in All Traumatic Brain Injuries

New research performed at the University of Illinois at Chicago College of Medicine has shown through diffusion tensor imaging, or Diffusion MRI, that patients with traumatic brain injury, even mild traumatic brain injury have structural changes in the white matter of their brains that account for cognitive impairments.

Diffusion tensor imaging is a new technology of magnetic resonance imaging (MRI) that measures the diffusion of water molecules in the brain. It also allows diffusion to be measured in multiple directions so that researchers can map the directions of the fibers and examine the connectivity of different regions in the brain. In particular the researchers used it to examine the connectivity of white matter in the brain and examine the structural changes found in white matter after traumatic brain injury. The researchers especially examined patients who had chronic traumatic brain injury.

The study was lead by Dr. Marilyn Kraus, associate professor of psychiatry and neurology at the University of Illinois at Chicago. She and her colleagues examined a range of patients with traumatic brain injury including mild and severe. What they found was that even patients who had no loss of consciousness or minimal loss of consciousness had structural changes in their white matter.

The researchers studied 37 traumatic brain injury patients. Twenty patients had mild TBI and 17 had moderate to severe TBI. All of the patients were studied six months after their injury date, and most of the people studied were people who were functioning very well and either working or in school. The researchers also studied 18 healthy people and gave them diffusion tensor imaging screenings. They also tested the healthy volunteers to evaluate their memory, their attention spans, and their executive functions. Executive functions are a set of cognitive functions that control and regulate other abilities and behaviors, particularly goal-oriented actions such as starting, stopping, and changing behavior.